You need wheel for you python version(32 or 64bit)
Here a run,i also make sure that pip is upgraded(9.0.1).
Here a run,i also make sure that pip is upgraded(9.0.1).
# Here you see that i have 32 bit version of Python C:\>cd python27 C:\Python27>python Python 2.7.12 (v2.7.12:d33e0cf91556, Jun 27 2016, 15:19:22) [MSC v.1500 32 bit (Intel)] on win32 Type "help", "copyright", "credits" or "license" for more information. >>> exit() # Upgrade pip C:\Python27>cd scripts C:\Python27\Scripts>pip install --upgrade pip Requirement already up-to-date: pip in c:\python27\lib\site-packages # It's okay C:\Python27\Scripts>pip -V pip 9.0.1 from c:\python27\lib\site-packages (python 2.7) # Install for 27 and 32 bit version of Python C:\Python27\Scripts>pip install PySide-1.2.2-cp27-none-win32.whl Processing c:\python27\scripts\pyside-1.2.2-cp27-none-win32.whl Installing collected packages: PySide Successfully installed PySide-1.2.2