Basically you can use just about any of the various Gui tools it all depends on preference or company restrictions (if any) and/or license issue (if any - e.g. GPL vs LGPL) Once those last two concerns are addressed the last part is which one do you want to learn -- I chose PyQt5 because it was the most robust and best documented (the latter being a big concern to me) and I have found it to quite nice to work with (once I learned that the Designer was definitely not necessary). Now I have not used Tkinter or any or the others since the project I was converting used PySide (another reason why I chose PyQt5 since its closest to PySide but is more current in its implementation than PySide2 is so I had to base my decision partially off of 2nd-hand information but I did a lot of cross-referencing of that 2nd-hand information before going with it. So with that said Good Luck with whatever Gui Tool you end up using.
P.S. If you do decide to use PyQt5 I run a Discord free Tutoring/Mentoring message server and can help you get going as well as provide help if you get stuck along the way -- drop a friend request to
DenniO#8137 to get an invite
