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Hello, i have 2 wsgi flask applications that every day they give me thsi error

Quote:pymysql.err.InterfaceError
pymysql.err.InterfaceError: (0, '')

if i restart my httpd(Apache) they stop appearing this error and load normally?

Any ideas why this happens?
Anyone familiar with PyMySQL that knows about this error?

and this error too:

Quote:pymysql.err.OperationalError
pymysql.err.OperationalError: (2006, "MySQL server has gone away (BrokenPipeError(32, 'Broken pipe'))")