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How to build of sophisticated Big Data predictive models (R, SAS or Python preferred) to test hypothetical relationships? THis is for clinical data analysis purpose. Thanks
That's a little complex for a post. There are a number of courses and books out there that are pretty good. The IBM course on Coursera for big data is good. There are a bunch of books on Amazon that can get you started as well.

There is no shortcut.
see: https://python-forum.io/misc.php?action=help&hid=19
and don't post just to get counts up!