.
.
.
      self.var1=StringVar(self.root)
      self.var2=StringVar(self.root)
      self.line1=CL.CustomFont_Label(self.root,textvariable=self.var1,
font_path=fontPath,size=36).grid(row=0,column=0,columnspan=5)
      self.line2=CL.CustomFont_Label(self.root,textvariable=self.var2,
font_path=fontPath,size=36).grid(row=1,column=0,columnspan=5)
      self.var1.set(self.pad('Stoker II'))
      self.var2.set(self.pad('Initializing'))
.
.
.
      self.root.mainloop()

#! /usr/bin/env python3.8
'''Docstring'''
import tkinter as tk
import random as rd
from functools import partial

class MyClass:
    def __init__(self, master):
        self.master = master
        self.master.columnconfigure(0, weight=1)
        self.master.rowconfigure(0, weight=1)
        self.lbl_search_text = tk.StringVar(value=self.randomtext(self.update_text))
        self.lbl_search = tk.Label(self.master, textvariable=self.lbl_search_text, bg='#fffeee')
        self.lbl_search.grid(row=0, column=0, sticky='new', pady=40)
        self.new_button()


    def update_text(self, textvar):
        self.lbl_search_text.set(textvar)

    def randomtext(self, myvar):
        mytext = ['Apple', 'Orange', 'Peaches', 'Tangerines', 'Banannas', 'Peanuts']
        rdword = rd.randint(0, len(mytext)-1)
        return mytext[rdword]

    def new_button(self):
        button = tk.Button(self.master, text='Change Word', command=partial(self.doit))
        button.grid(column=0, row=1, sticky='nw', pady=10, padx=10)

    def doit(self):
        self.lbl_search.destroy()
        MyClass(self.master)



root = tk.Tk()
root.geometry('300x200+50+50')
MyClass(root)
root.mainloop()

Output:
Apple
Orange
Peanuts