Stock Return calculation problem

[perfringo]

I totally understand and I did it, exactly what you wrote in the first time but as I am going to use different weights (w1, w2...) for each assets and The computation of my last formula (Base * (1 + return1*w1 + return2*w2...) I think I need to separate them...

Maybe you should try it again. I can't see any advantages of having separate variables/names compared to list/tuple/dictionary approach. You can access both by name and in container they become iterable in case you need to access them dynamically:

>>> weights = (0.2, 0.3, 0.4)
>>> weights[0]
0.2
>>> for weight in weights: 
...     print(weight)
...
0.2
0.3
0.4
>>> weights = {1: 0.2, 2: 0.3, 4: 0.4}
>>> weights[2]
0.3

You should also think about future self. If you return to your code in two days/weeks/months do you remember what tickers_3 / return_3 were? Was it AMZN or APPL?