Controlling Python Program From Django Front End

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Just like any other program, this one could listen to a port for a connection from the website for some message which can be interpreted as a command. After that, it does its things and returns a response back to the website which you can see.
JSON stands for JavaScript Object Notation. Perhaps every programming language can deal with it. It has a simple structure, it's human-readable and consists of key-value pairs. It looks like this:

"person" {
    "first": "Donald",
    "last": "Trump",
    "characteristics": ["president of the USA", "businessman"]
    }

The messages could be a simple text too. It depends on what suits your needs.