Manipulating an Excel Workbook

[Stanimal]

Hello! I currently have an excel spreadsheet that is showing me data but I need to be able to manipulate that data, find exceptions, and suggest corrections. From what I can tell, I am not sure I can do it in excel itself. My question is, can I write a code in python that will interact with that spreadsheet in the way I need it to? I used to have a basic understanding of python but have since gotten rusty. Is it worth re-learning python to be able to manipulate my spreadsheet? Any suggestions or help is appreciated! Thank you!