Can Python build graphical screens like this?

[Larz60+]

This? https://pypi.python.org/pypi/synapse
I think this interfaces to the Apache product

You can also create from scratch using wxpython, PyQt5 and several other GUI packages.
You probably use Tkinter, but I wouldn't recommend it for an application of this caliber.

I also found this: http://python-evdev.readthedocs.io/en/latest/
which might work