wxPython would abstract GTK, but an excellent choice due to the fact that it's very established. It's currently being updated (Phoenix branch) targeting Python 3.x Doing a recent google have discovered that wxQT provides support for QT5 most notably so that's very good and lays a solid foundation for wxPython.
There are also PyQT and Kivy among many others. Kivy targeted mobile platforms initially but now also aims at the desktop platform; supports using either CPU (blitting) or GPU rendering at your preference and provides interface support for external layout files similar to css. Not really familiar with PyQT or QT in general, but have heard many good things about both.
There are also PyQT and Kivy among many others. Kivy targeted mobile platforms initially but now also aims at the desktop platform; supports using either CPU (blitting) or GPU rendering at your preference and provides interface support for external layout files similar to css. Not really familiar with PyQT or QT in general, but have heard many good things about both.