with os.open?

[Gribouillis]

See also contextlib.contextmanager for a simplified interface and also contextlib.closing and the like

import contextlib

@contextlib.contextmanager
def my_open(*args, **kwargs):
    fd = os.open(*args, **kwargs)
    try:
        yield fd
    finally:
        os.close(fd)

with my_open(my_thing) as desc:
    ...