Read and write active Excel file

[Larz60+]

You can, and save in place, but that's not the proper way to do it because if you make a mistake, you will have overwritten you original spreadsheet.
Instead save to a new spreadsheet and when satisfied, you can rename it.

Example:

from openpyxl import load_workbook

excelfile = 'runways.xlsx'                # modify to your spreadsheet name
excelout = 'ModifiedRunways.xlsx'   # ditto

wb = load_workbook(excelfile)
sheet_ranges = wb['runways']        # modify to your sheet name
print(sheet_ranges['F2'].value)

sheet_ranges['F2'] = 'New Guy'

wb.save(excelout)