Do you want it to figure out that because the TZ offset is -05:00 that it should be EST? Unfortunately, that's only an assumption. Other timezones besides US/Eastern may currently have a 5 hour offset.
Or do you want to take the input time and display it in the current US/Eastern local time? If you have 3.9 and a machine with a timezone DB (that probably means installing the tzdata module if you're on windows), then the following would work.
>>> u = '2020-11-02T08:30:00-05:00'
>>> import datetime
>>> import zoneinfo
>>> datetime.datetime.fromisoformat(u).astimezone(zoneinfo.ZoneInfo("US/Eastern")).strftime("%Y-%m-%d %H:%M:%S")
'2020-11-02 08:30:00'